뇌세포시각화 연구실

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PROJECT

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Develop a tool for

Vizualizing Brain Cells

SINCE.2020

ABOUT VizBrCells

뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

미지의 뇌세포를 손쉽게 볼 수 있는

시각화 도구들을 만들고자 합니다.

OUR Scheme

1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

4. 세포 특이적 염색의 분자 메커니즘의 분석

ABOUT VizBrCells

뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

미지의 뇌세포를 손쉽게 볼 수 있는

시각화 도구들을 만들고자 합니다.

SCHEME

1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

4. 세포 특이적 염색의 분자 메커니즘의 분석

COLLABORATION

Through active co-work with chemists, novel fluorescent probes have synthesized

CREDENTIAL

By applying a creative screening platform, we give own ID to an unsung chemical

CONTRIBUTION

After identifying its brain target, we can provide an innovative tool for tracking a type of brain cells

Primary glial culture

Microglia (CDr20)

Nuclei (Hoechst33342)

Primary glial culture

1. Normal condition

2, 3. ADP treat

1. Phase contrast

2. CDr20 fluorescence

OUR TEAM

We are the bridge of science.

(Click image for more details)

Lab Head, 김범수 (Beomsue Kim, Ph.D.)

20-Current, Senior Researcher, Neural Circuit Group, Korea Brain Research Insisisute (KBRI)

14-19, Research Fellow, Singapore Bioimaging Consortium, A-STAR, Singapore

13-14, Research Fellow, Dpt. Chemistry, NUS, Singapore

09-13, Research Fellow, Dpt. Pharmacology, Ajou University

05-09, Ph.D., Neural Science & Technology, Ajou University, Korea

03-04, Visiting Scholar, Dpt. Pediatrics, UTHSC, TN, USA

01-03, M.Sc, Life Science, Hanyang University, Korea

97-01, B.Sc., Biology, Hanyang University, Korea

김원주 (Ph.D.)

박사후 연수연구원 (2023.05 - )

고동완 (M.Sc.)

석사후 연수연구원 (2022.03 - )

김민지 (M.Sc.)

석사후 연수연구원 (2023.05 - )

If you are interested to join us as a research fellow (MSc/PhD holder) or a gradurate student,

please send e-mail with your CV to kimbs@kbri.re.kr.

CONTACT

PROJECT

SINCE.2020~

뇌세포 특이적 형광저분자 물질 개발: Brain cell-type-specific fluorescent small molecules

퇴행성 뇌질환 진단기술 개발: Diagnostic tools for neurodegenerative disorders

신경회로 내 신경/교세포 네트워크 분석 기술 개발: Technical tools for studying neural-glial networks in neural circuits

인간 뇌발달에 환경유해인자가 미치는 영향 연구: Effects of environmental hazards on human brain development

면역세포 분석에 생리활성 형광저분자 물질의 적용: Bioactive fluorescent small molecules for immune cell identification

저분자물질의 작용기전 및 약물대사 연구: MOA/DMPK studies for small molecules

PUBLICATIONS (selected)

Unraveling the Mode of Action of a Neuron-Specific Fluorescent Probe, NeuO: Intracellular Phosphorylation Through PAK6 Kinase. Angew Chem Int Ed Engl. (2025) e202511160 (Online ahead of print) Kim B*, Ko D, Kim SB, Kim S, Kim M, Hong NK, Park SY, Kim W, Lee BC, Lee Y, Sim T, Chang YT*. (*Co-corresponding)

Discovery of asymmetric pyridinium-based fluorescent probes with large Stokes shifts for live neural stem/progenitor cells. J Mat Chem B (2025) doi.org/10.1039/D5TB00857C (Online ahead of print) Han YR^#, Ko D^#, Hwang Y, Choi MA, Kim D-G, Lee JY*, Kim B*. (*Co-corresponding)

Unraveling the enigma: housekeeping gene Ugt1a7c as a universal biomarker for microglia. Front. Psychiatry (2024) 15: 1364201. W Kim, M Kim, B Kim. (Perspective)

Distinctive Labeling of Live Monocytes and Neutrophils with a Single Fluorescent Molecule. Chemosensors (2023) 11(5): 265. S Kim, M Fukuda, JY Lee, YT Chang, HS Je, B Kim.

LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition. Anim. Cells Syst. (2022) 26(6): 380–387. B. Kim*, YH Suh, E Joe*. (*, Co-corresponding authors)

A brief review of non-invasive brain imaging technologies and the near-infrared optical bioimaging. Appl Microsc. (2021) 51(1):9. B Kim*, H Kim, S Kim, YR Hwang. (*, Corresponding author)

Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate. Angew Chem Int Ed Engl. (2019) 58(24):7972-7976. B Kim*, M Fukuda*, JY Lee, D Su, S Sanu, A Silvin, ATT Khoo, T Kwon, X Liu , W Chi, X Liu, S Choi, DSY Wan, SJ Park, JS Kim, F Ginhoux, HS Je, YT Chang. (Frontispiece, VIP, *; Co-first authors)

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Nat Commun. 2019 Mar 7;10(1):1111. SJ Park*, B Kim*, S Choi*, S Balasubramaniam, SC Lee, JY Lee, HS Kim, JY Kim, JJ Kim, YA Lee, NY Kang, JS Kim, YT Chang. (*; Co-first authors)

A Fluorescent Probe for Neural Stem/Progenitor Cells with High Differentiation Capability into Neurons. Chembiochem. 2016 Nov 17;17(22):2118-2122. B Kim, S Feng, SW Yun, C Leong, R Satapathy, SY Wan, YT Chang. (Front Cover)

Alumni
Name	Position	Period	Current
Aleksander Szawan	연구인턴	2024.10-2025.02	Cardiff. Uni. student
나도영	연구원(M.Sc)	2021.06- 2023.12	-
김송희	석사후연수연구원(M.Sc)	2021.03-2023.09	아일랜드 거주
조민정	연구조원	2022.10-2023.03	-
황영란	석사후연수연구원 (M.Sc)	2020.05-2022.11	Ph.D. student
장규림	연구인턴	2021.01-2021.02	DIGIST student
김홍민	박사후연수연구원 (Ph.D)	2020.10-2020.12	Company

ADRESS

61, Cheomdan-ro, Dong-gu, Daegu, 41062. Korea

PHONE NUMBER

053-980-8480

E-MAIL

kimbs@kbri.re.kr

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