뇌세포시각화 연구실

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PROJECT

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Develop a tool for

Vizualizing Brain Cells

SINCE.2020

글 번호	카테고리	제목	작성일
4	랩소식	석사후/박사후 연수연구원 모집	2021-01-11
3	랩소식	대학생 대상, 학점인정 현장실습 교육과정 참여 가능	2020-08-04
2	랩소식	블러그와 연동 되었습니다.	2020-08-03
1	랩소식	게시판이 개설되었습니다 1	2020-07-29

글쓰기

ABOUT VizBrCells

뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

미지의 뇌세포를 손쉽게 볼 수 있는

시각화 도구들을 만들고자 합니다.

OUR Scheme

1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

4. 세포 특이적 염색의 분자 메커니즘의 분석

ABOUT VizBrCells

뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

미지의 뇌세포를 손쉽게 볼 수 있는

시각화 도구들을 만들고자 합니다.

SCHEME

1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

4. 세포 특이적 염색의 분자 메커니즘의 분석

COLLABORATION

Through active co-work with chemists, novel fluorescent probes have synthesized

CREDENTIAL

By applying a creative screening platform, we give own ID to an unsung chemical

CONTRIBUTION

After identifying its brain target, we can provide an innovative tool for tracking a type of brain cells

Primary glial culture

Microglia (CDr20)

Nuclei (Hoechst33342)

Primary glial culture

1. Normal condition

2, 3. ADP treat

1. Phase contrast

2. CDr20 fluorescence

OUR TEAM

We are the bridge of science.

(Click image for more details)

Lab Head, 김범수 (Beomsue Kim, Ph.D.)

20-Current, Senior Researcher, Neural Circuit Group, Korea Brain Research Insisisute (KBRI)

14-19, Research Fellow, Singapore Bioimaging Consortium, A-STAR, Singapore

13-14, Research Fellow, Dpt. Chemistry, NUS, Singapore

09-13, Research Fellow, Dpt. Pharmacology, Ajou University

05-09, Ph.D., Neural Science & Technology, Ajou University, Korea

03-04, Visiting Scholar, Dpt. Pediatrics, UTHSC, TN, USA

01-03, M.Sc, Life Science, Hanyang University, Korea

97-01, B.Sc., Biology, Hanyang University, Korea

김원주 (Ph.D.)

박사후 연수연구원 (2023.05 - )

고동완 (M.Sc.)

석사후 연수연구원 (2022.03 - )

김민지 (M.Sc.)

석사후 연수연구원 (2023.05 - )

If you are interested to join us as a research fellow (MSc/PhD holder) or a gradurate student,

please send e-mail with your CV to kimbs@kbri.re.kr.

CONTACT

PROJECT

SINCE.2020~

1. 소교세포의 세포소기관 관찰법 개발 (Microglial specific fluorescent probe & Click chemistry)

2. 인간 뇌세포 추적기술 개발 (A human brain cell type-specific probe)

3. 3차원 인간 뇌조직 배양체 유도 (iPSC-derived brain organoid)

PUBLICATIONS

Distinctive Labeling of Live Monocytes and Neutrophils with a Single Fluorescent Molecule. Chemosensors. 2023 Apr 29; 11(5):265. Kim S, Fukuda M, Lee JY, Chang YT, Je HS, Kim B#

LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition. Animal Cells Syst. 2022 Dec 22;26(6):380-387. Kim B#, Suh YH, Joe E# (1st, Co-corresponding)

Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library. RSC Chem. Biol. 2021 Aug 20;2(6): 1590-1593. Co-author

A brief review of non-invasive brain imaging technologies and the near-infrared optical bioimaging. Applied Miscroscopy 2021 51, 9. Kim B*, Kim H, Kim S, Hwang Y. #, (Corresponding )

A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2. J Am Chem Soc. 2019 Sep 18;141(37):14673-14686. Kim JJ, Lee YA, Su D, Lee J, Park SJ, Kim B, Jane Lee JH, Liu X, Kim SS, Bae MA, Lee JS, Hong SC, Wang L, Samanta A, Kwon HY, Choi SY, Kim JY, Yu YH, Ha HH, Wang Z, Tam WL, Lim B, Kang NY, Chang YT.

Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate. Angew Chem Int Ed Engl. 2019 Jun 11;58(24):7972-7976. Kim B#, Fukuda M#, Lee JY, Su D, Sanu S, Silvin A, Khoo ATT, Kwon T, Liu X, Chi W, Liu X, Choi S, Wan DSY, Park SJ, Kim JS, Ginhoux F, Je HS, Chang YT. (Frontispiece, VIP)

Development of a Universal Fluorescent Probe for Gram-Positive Bacteria. Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8426-8431. Kwon HY, Liu X, Choi EG, Lee JY, Choi SY, Kim JY, Wang L, Park SJ, Kim B, Lee YA, Kim JJ, Kang NY, Chang YT.

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Nat Commun. 2019 Mar 7;10(1):1111. Park SJ#, Kim B#, Choi S#, Balasubramaniam S, Lee SC, Lee JY, Kim HS, Kim JY, Kim JJ, Lee YA, Kang NY, Kim JS, Chang YT. (Co-first)

A Fluorescent Probe for Neural Stem/Progenitor Cells with High Differentiation Capability into Neurons. Chembiochem. 2016 Nov 17;17(22):2118-2122. Kim B, Feng S, Yun SW, Leong C, Satapathy R, Wan SY, Chang YT. (Front Cover)

Alumni
Name	Position	Period	Current
나도영	연구원(M.Sc)	2021.06- 2023.12	-
김송희	석사후연수연구원(M.Sc)	2021.03-2023.09	아일랜드 거주
조민정	연구조원	2022.10-2023.03	-
황영란	석사후연수연구원 (M.Sc)	2020.05-2022.11	Ph.D. student
장규림	연구인턴	2021.01-2021.02	DIGIST student
김홍민	박사후연수연구원 (Ph.D)	2020.10-2020.12	Company

ADRESS

61, Cheomdan-ro, Dong-gu, Daegu, 41062. Korea

PHONE NUMBER

053-980-8480

E-MAIL

kimbs@kbri.re.kr

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